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If the vitamin is administered by injection in response to a deficiency and enters the bloodstream directly in high concentrations, an immunologic reaction with skin reactions is possible

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Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W

AOD-9604, a synthetic fragment derived from the C-terminal region of human growth hormone, has been subjected to extensive clinical evaluation involving over 900 participants across six randomized controlled trials