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In addition, a small pilot safety study published in Alternative Therapies in Health and Medicine showed that intravenous infusions of BPC-157 up to 20 milligrams were well-tolerated with no reported adverse effects in healthy adults, providing initial evidence that the peptide can be administered safely, a necessary step before larger efficacy trials on healing outcomes are conducted

Furthermore, histopathological examination revealed cellular inflammatory infiltration (which leads to endothelial migration and production of chemotactic agents), angiogenesis (granulation tissue formation), epithelialization, extracellular matrix deposition (collagen hyperproliferation), and wound contraction (scar decrease)

Note: Always consult a qualified healthcare provider before use

In dermatology, CPPs exhibit therapeutic potential by regulating collagen synthesis, modulating melanogenesis, and alleviating inflammation in atopic dermatitis

doi: 10.3389/fmolb.2025.1638042 Received 02 June 2025 Accepted 11 August 2025 Published 04 September 2025 Volume 12 - 2025 Edited by Lidija Milkovic, Rudjer Boskovic Institute, Croatia Reviewed by Sathish Sivaprakasam, Texas Tech University Health Sciences Center, United States Jos Daz-Chvez, Instituto Nacional de Cancerologa (INCAN), Mexico Updates Copyright 2025 Gao, Jiang, Sun, An, Sun, Tang, Kang, Zhao, Li, Liu, Ji and Lian