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In some embodiments, the otic formulation or composition comprises about 0.2% by weight of the carbomer

Avoid combining directly with strong acids, low-pH exfoliating systems, strong oxidizers, or high levels of free metal chelators

296 , G1140G1149 (2009)

530532 Canonical MarRs that repress the expression of drug efflux pumps may bind antibiotics or other small organic molecules leading to the transcriptional depression of the genes associated with an adaptive response to antibiotic stress, e.g., efflux systems