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In addition, candidalysin activates the MAPK pathway in endothelial cells and secretes CXCL8 (Swidergall et al., 2019)

[DOI] [PubMed] [Google Scholar] 131.Singal A.K., Bataller R., Ahn J., Kamath P.S., Shah V.H

[DOI] [PubMed] [Google Scholar] 222.Menon D., Board P.G

Activation of mTOR and upregulation of HIF-1 trigger enhanced glycolytic reprogramming in innate immune cells, which fulfills the elevated metabolic demands of trained immunity and synergizes with epigenetic remodeling to sustain the long-term pro-inflammatory and anti-pathogen memory phenotype of innate cells ( C

Safety: Clinically tested oral supplements are safer for long-term use