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According to the cited figure 3[14], the increase of NADPH concentration from 2,5 mM [1] up to 10 mM also increases the velocity of GR and the GSH reserve levels, that are increased from 10 mM up to 100 mM, in such a way to always saturate GP activity

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As mentioned previously, inflammation can induce myocardial hypertrophy and fibrosis during cardiac injury, destroy BBB and lead to neurological defects in the ischemic region, promoting the progress of CCVDs

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