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A PubMed study found that microneedle pretreatment substantially improved GHK-Cu skin penetration compared with intact skin

In addition, senescent cells gain an irreversible senescence-associated secretory phenotype (SASP), secreting soluble factors (such as chemokines and interleukins) and matrix-degrading enzymes, altering the microenvironment and affecting the behavior of the surrounding cells (120, 121)

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and Undheim, Eivind A