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Genetic variation in HSD17B13 reduces the risk of developing cirrhosis and hepatocellular carcinoma in alcohol misusers

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PubMed: 12750433 KPV oral delivery via PepT1 PepT1 transporter uptake in inflamed intestinal tissue, murine IBD models, intracellular NF-B and MAP kinase suppression at nanomolar concentrations, PepT1-knockout loss-of-function proof: Kannengiesser K et al

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Though the gene encoding DSIP has not been identified and its receptor remains unknown, emerging studies indicate that its activity may be mediated through NMDA receptors in the brain and 1-adrenergic pathways in peripheral tissues