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Relative luciferase activity was expressed as the RLUC/FLUC ratio relative to the control (LC-GFP Mock) in U373 ( E ), U87 ( F ), and HS683 ( G ) cells (n = 3 per group)

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The peptide reduces myofibroblast differentiation by downregulating -smooth muscle actin (-SMA) and collagen type I alpha 1 (Col1a1) expression, key markers of activated fibroblasts

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[] Conventional pharmacotherapy using non-steroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs such as methotrexate and leflunomide can control inflammation but is often limited by adverse effects, high cost, and risk of infection