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We also found a notable increase in gametocyte numbers when we used RBCs that were pre-loaded with homocysteine concentrations known to be present in plasma of malaria patients 12

Phosphatidylinositol-3,4,5-triphosphate activates downstream AKT and then regulates the proliferation, survival and energy metabolism of osteoblasts through mammalian target of rapamycin, BCL-2-antagonist of cell death, forkhead box O1, and other pathways [28, 29]

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