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View Study PCO-02 Safety and Pharmacokinetics Trial (Phase 1)

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Transl Psychiatry 11(1):503 Meyrel M, Rolland B, Geoffroy PA (2020) Alterations in circadian rhythms following alcohol use: a systematic review

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BPC-157 has been shown to: Increase fibroblast recruitment Speed up collagen deposition Improve tendon-to-bone interface healing Reinforce ligament remodeling after trauma This makes it highly effective for: Partial tendon tears Post-surgical repair Muscle strains and chronic tendonitis Application of BPC-157 significantly improved fibroblast activity and collagen fiber orientation in Achilles tendon repair models. Chang et al., American Journal of Sports Medicine 3

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In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

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