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Currently, the neurohormonal antagonists (ACE-inhibitors, beta-blockers, angiotensin receptor blockers, and mineralocorticoid receptor antagonists) are recommended for CHF as cornerstones [2, 3]

Reduced Pigmentation Marks: Over time, dark spots, scars, or melasma fade

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Concurrent Use: What Evidence Supports Clinical practice guidelines recommend sequential monotherapy: start with one agent, titrate to target dose, and assess response over 12-16 weeks