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Nevertheless, the relationships between IGFs and numerous microenvironmental components, such as NK cells, neutrophils and even the microbiota, remain to be elucidated and incorporating other targets or combination therapies to address the individual and tissue heterogeneity of tumors is crucial
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Glutathione S -Transferases (GSTs) GSH has many biological roles, including (1) defense against reactive oxygen species and free radicals, (2) defense against reactive electrophiles, though the action of GSTs (3) carrier of cysteine in a less reactive form, (4) cofactor in several enzyme reactions, (5) participation in eicosanoid biology, (6) maintenance of cellular redox state, and (7) transport of cysteine (e.g., Taniguchi et al., 1989)
Uric acid: its relationship to renal hemodynamics and the renal renin-angiotensin system
