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However, in genetically predisposed individuals, a subset of autoreactive T cells can evade these mechanisms, become activated, proliferate, and differentiate, initiating an autoimmune cascade (Fig

The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models

Arch Dermatol 132:11851193