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No freezing reconstituted peptides causes ice crystal formation that physically shears peptide chains, resulting in irreversible denaturation

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More recently, a newer generation 3-AR agonist, Mirabegron, which is approved for incontinence, showed increased BAT activity in healthy patients

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It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Green et al., 2017)