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Moreover, a study conducted in women treated with radiotherapy for breast cancer reported that those who smoked at the time of treatment had a significantly increased risk of developing squamous cell carcinoma later on, highlighting a synergistic interaction between tobacco smoke and IR (141)

Once these cis-acting regulatory elements are identified, the transcription factor proteins required for transcriptional activation can be also determined

Mechanism: Synergistic pro-repair, angiogenic, and anti-inflammatory actions to support soft-tissue integrity

These effects contribute to its role in promoting tissue healing, improving flexibility, and supporting overall recovery [4]

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