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"Saunas increase a transcription factor called Nrf2, which regulates genes responsible for antioxidant and anti-inflammatory functions."Sauna therapy also aids in the regulation of pro and anti-inflammatory cytokines IL-6 and IL-10, Winkelmann added, which decreases chronic inflammation and facilitates a more appropriate inflammatory response in the future

One study found that compounded drugs were responsible for 45 percent of drug recalls in the US between 2012 and 2021, despite accounting for just 1 to 3 percent of prescriptions

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Research has shown that miR-93-5p regulates the NF-B signaling pathway and promotes apoptosis and ferroptosis in GCs (170)

So in ALS, rather than driving pathology, the baseline microbiome might be trying to counteract it, and losing key microbes removes that brake on microglial activation