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Assessing heterogeneity of treatment effect in real-world data

In males, the core fertility factors consist of spermatogenesis, seminal plasma content, and the health of testicular tissue and ducts

Adverse effects are rare and mild

This limits efficacy and increases the risk of off-target effects, including neuropsychiatric side effects and motor complications 77

Bacteroides thetaiotaomicron and Lactobacillus johnsonii generate fatty acids, particularly oleic acid and palmitic acid, regulate inflammatory immune responses, and eliminate Candida glabrata in the DSS-induced colitis mouse model ( Current antifungal drugs Currently, the first-line clinical antifungal drugs include polyenes (e.g., amphotericin B), azoles (e.g., fluconazole) and echinocandins (e.g., caspofungin) (Wiederhold, 2017