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While lactate has been reported to promote ferroptosis in normal cellular contexts by modulating iron homeostasis and lipid peroxidation, tumor cells appear to exploit lactate signaling pathways to reinforce their anti-ferroptotic defenses

Rats were assessed for fine motoric impairment with modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale) that can detect recovery of both proximal and distal forelimb function including digit movements during a naturally occurring behavior that does not require extensive training or deprivation to enhance motivation (64)

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