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CNS Drugs 32 , 939949 (2018)

Similarly, rapamycin reduces seizures by inhibiting mTOR, a kinase that mediates positive feedback to the VEGF pathway, which decreases BBB leakage and reduces activation of microglia and macrophages (182)

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Also, glutamate excitotoxicity NMDA-mediated intra-neuronal calcium overload elevates NO synthesis contributing to oxidative stress particularly the production of reactive nitrogen species which are able to cause defects in DNA and protein phosphorylation pathway (85)

10.1016/j.biopsych.2008.10.040 39 KowiaskiP.LietzauG.SteligaA.CzubaE.LudkiewiczB.WakowM.et al (2018)