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The critical role of Gpx4 is underscored by the fact that whereas Gpx1-knockout mice are fully viable, Gpx4-knockout animals demonstrate embryonic lethality, and Gpx4 +/ cell lines are markedly sensitive to inducers of oxidative stress, including -irradiation, tert -butyl-hydroperoxide, and hydrogen peroxide, as compared with cell lines derived from wild-type control littermates (147)

MMP9 mRNA is a potential diagnostic and treatment monitoring marker for PTSD: evidence from mice and humans

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Vascular normalization seeks to transiently improve vessel structure and function, including pericyte coverage, perfusion, oxygenation and drug distribution [11, 12, 68]