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The copper ion component serves as a cofactor for essential enzymes involved in collagen and elastin synthesis, while the tripeptide sequence provides the targeting mechanism for cellular uptake

Therefore, in this review our aim is to bring all IGF-1 information regarding metabolism together with the objective of offering clear insight into the issuethis way clarifying how miss-regulation of the GH/IGF-1/insulin axis can lead to metabolic disorders such as MetS and diabetes

Notably, inflammation and stress not only augment TRP to KYN conversion (via IDO upregulation) but also increase levels of neurotoxic KYN metabolites (due to enhanced microglial over astrocytic throughput) [118]

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