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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Knezevic M., Gojkovic S., Krezic I., Zizek H., Malekinusic D., Vrdoljak B., Vranes H., Knezevic T., Barisic I., Horvat Pavlov K., et al

Genetic knockout and pharmacological blockade of both Aldh1a1 and GAT1 have been reported to reduce GABAergic inhibitory post-synaptic currents (IPSCs) in striatal DA/GABA neurons (Tritsch et al., 2014

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Studies suggest the compound may enhance the brain's intrinsic capacity for repair through mobilization of existing plasticity mechanisms rather than requiring exogenous cell replacement therapies