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B., Shivdasani, R

In 1955, an American doctor named Harry Eagle made a surprising discovery about cancer cells growing in a dish: They required ridiculous amounts of glutamine

(PubMed) Mann EA, Baun MM, Meininger JC, Wade CE

By inhibiting P-gp, these agents enhance cellular drug retention but may inadvertently increase systemic drug concentrations, posing toxicity risks for narrow-therapeutic-index medications (e.g., chemotherapeutics, cardiovascular drugs) (32, 8890)