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Neutrophils, mononuclear phagocytes, and lymphocytes accumulate vitamin C to high concentrations, which can protect these cell types from oxidative damage

This effect is achieved by amplifying oxidative stress and triggering apoptosis mediated by endoplasmic reticulum (ER) stress

In addition, protein s -cysteinylation levels distinguish healthy controls from those with neoplasms, suggesting that discriminating plasma cysteine pools might be valuable for early diagnosis and outcome prediction

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They suppressed the activity of sHB-EGF to promote ovarian tumor cell migration and invasion by inhibiting the EGFR signaling pathway 110