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High-quality randomized trials focused specifically on weight outcomes in non-deficient populations would clarify these uncertainties

For example, a review by Gwyer and colleagues (2019) concluded that while studies have reported findings across experimental models, the majority of the evidence comes from laboratory and animal research

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Pregnancy All TNF inhibitors are labeled as pregnancy Class B, meaning that animal studies have not shown any risk to the fetus but there are no well-controlled human studies to confirm this