Building a collision cross section library of pharmaceutical drugs using the Vion IMS QTof platform: Verification of system performance, precision and deviation of CCS measurements
Trichotillomania should also not be confused with Body Dysmorphic Disorder, a condition in which a person experiences obsessions and compulsions related to their physical appearance
Methylene blue-induced serotonin syndrome presenting with ocular clonus and failure of emergence from general anesthesia
What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
MECP2 gene mutations lead to Rett syndrome, an X-linked neurodevelopmental disorder primarily affecting females
