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Comparing them is less about "which is best" and more about understanding three distinct approaches to the same research domain

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A 2017 meta-analysis of data from 15 trials, including more than 71,000 participants at risk of or with existing CVD, showed that B-vitamin supplementation had no significant effect on risk of myocardial infarction (heart attack) or all-cause mortality but reduced risk of stroke by 10% (RR, 0.90

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This presents a meaningful clinical concern, particularly in populations exposed to polypharmacy or managing complex comorbidities