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High-dose oral B12 can still be effective for those with mild absorption problems

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Yes, B12 shots can support weight loss, especially when combined with a healthy diet and regular exercise

The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake

5-Amino-1MQ At a Glance What 5-Amino-1MQ Is (Composition & Mechanism) 5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of NNMT nicotinamide N-methyltransferase