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One clinical trial showed that ipamorelin administered to healthy volunteers produced dose-dependent, pulsatile increases in growth hormone concentrations with predictable pharmacokinetics and without serious adverse effects, establishing its ability to stimulate GH release

135 In addition to these effects, there is growing evidence from human and murine studies that gut microbiota can influence BBB permeability in health and disease, 136-139 and that ageing may drive further gut microbiota changes or dysbiosis, 140-142 compounding BBB changes

C.DuhamelA.Guyon DelannoyP.et al (2022)

10.7717/peerj.16875 31 Di RaimoR.MizzoniD.AloiA.PietrangeloG.DoloV.PoppaG.et al (2024)

(2003) 111(5 Pt 1):10029