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These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione

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Besides, the detection of zinc levels and zinc-related molecular alterations in biological samples may serve as diagnostic biomarkers for various diseases, aiding early detection and guiding treatment decisions

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By disrupting FOXO4-p53 interactions, it promotes apoptosis in senescent cells, reducing inflammation and improving cellular health (3)

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