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c-KIT-mediated ERK signaling pathway can induces CREB phosphorylation to activate melanin synthesis on one hand, and on the other hand, the activation of ERK signaling has been demonstrated to phosphorylate MITF at the serine 73 residue, which leads to the ubiquitination and degradation of MITF, this is the feedback mechanism of the ERK pathway to regulate melanin production (3,35)

Branched-chain amino acids and muscle protein synthesis in humans: Myth or reality

Garca Puig, J

This mechanism is activated via other pro-apoptotic proteins released from the mPTP, such as AIF or endonuclease G

Apply a dime-sized amount to face and neck