This present study was designed to investigate the effects of the treatment with the PPAR-beta/delta agonist GW0742 on hepatic energy metabolism and liver stress in a diet-induced obesity model
Eat well, live better and stay healthy
J Chem Pharm Res 7(6):687707 Krupa J, Murugan R, Gangapriya P et al (2022) Moringa concanensis Nimmo
Increased cell-free DNA is associated with oxidative damage in patients with schizophrenia
Also, hyperactivation of the hypothalamus-pituitary-adrenal axis, altered metabolic clearance of cortisol, coupled with changes in corticosteroid-binding globulin and corticosteroid receptor sensitivity may contribute to increasing cortisol availability [79, 84,85,86,87,88,89] Together, these processes create a state of tissue-specific cortisol excess, promoting visceral adiposity, insulin resistance, and metabolic dysfunction [79, 84,85,86,87,88,89] It is however noteworthy that the relationship between cortisol levels and obesity are inconsistent, as some investigators have documented positive, null, or even inverse associations, likely reflecting complexities in glucocorticoid production, variable cortisol clearance, and metabolic regulation [84, 90,91,92,93,94,95]
