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AOD 9604 + NAD+ Combining AOD 9604 with NAD+ therapy at Perfect B in Doral targets two separate axes of metabolic function: NAD+ addresses cellular energy metabolism, mitochondrial efficiency, and metabolic resilience at the enzymatic level, while AOD 9604 drives fat mobilization from adipose tissue

AOD-9604 Pharmacokinetics & Metabolism Absorption & Distribution AOD-9604 exhibits unusual pharmacokinetic properties for a peptide, demonstrating activity via multiple administration routes in preclinical models: Oral bioavailability confirmed in pig and rodent studies, an uncommon characteristic for peptide compounds Rapid systemic distribution following intraperitoneal administration in mice (15-30 minutes) Following IV administration in pigs, AOD-9604 and degradation fragments appeared rapidly in plasma Oral administration showed slower kinetics but similar degradation product profiles Distribution studies using radiolabeled peptide (C-14-AOD9604) in rats revealed: Elevated concentrations in pineal body and thyroid tissues Distribution to all non-CNS tissues examined Minimal penetration of blood-brain barrier Tissue-specific accumulation patterns suggesting potential targeting mechanisms Metabolism & Elimination The metabolic fate of AOD-9604 involves rapid degradation through sequential N-terminal amino acid removal,: Plasma half-life of approximately 3 minutes following IV administration in pigs (compared to 21 minutes for full-length growth hormone) Sequential amino-terminal truncation represents the primary degradation pathway Principal metabolites identified in vivo include -2 amino acid and -3 amino acid fragments These truncated fragments retain some reduced in vitro anti-lipogenic activity A significant pharmacokinetic paradox exists: despite rapid plasma clearance (peptide undetectable at 56 minutes in spiked plasma studies), biological effects on body weight and fat metabolism persist for hours to days

Before taking, speak with your doctor if you are allergic to vitamin b12, have a genetic condition called optic atrophy, have blood in your urine, polycythemia, an ongoing infection, low iron or folate levels, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed

Most people begin to feel improvements in energy and mental clarity within a few days, though mood, nerve, and red blood cell benefits continue to build over several weeks

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