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Mounting evidence highlights the critical role of renal tubular ferroptosis in DKD progression [34, 35]

Factors Contributing to Glutathione Depletion: Factors such as chronic stress, poor diet, environmental toxins, and certain medical conditions can deplete glutathione levels, increasing the importance of monitoring and maintaining optimal levels

Future opportunities include hybrid nanoplatforms that integrate redox responsiveness with imaging and enhanced safety, as well as the use of patient-specific GSH/GSSG profiles to guide individualized therapy

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