Studies have demonstrated a strong association between intestinal microbiota and diseases like gastrointestinal diseases (e.g., gastroenteropancreatic neuroendocrine neoplasms, inflammatory bowel disease, and colon cancer), psychiatric diseases (e.g., Alzheimers disease, multiple sclerosis, and Parkinsons disease), respiratory diseases (e.g., bronchial asthma, chronic obstructive pulmonary disease, and infectious lung diseases), cardiovascular diseases (e.g., atherosclerosis), metabolic diseases (e.g., obesity and type 2 diabetes), immune diseases (e.g., rheumatoid arthritis and ankylosing spondylitis), and so on ( However, relatively sparse research has been done on the possible link between the gut microbiota and thyroid disease, where the concept of thyroid-gut-axis was proposed lately ( Table 1 , Figure 1 )
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Elevated CRP correlates directly with the degree of RA disease activity and is a strong independent predictor for the progression of radiologic joint damage (Shmerling & Greisen, 2025)
Figure 5 shows the phylogenetic positions of strain OU-01, with representatives of the family Desulfovibrionaceae