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However, the precise mechanism by which it does so is controversial, inasmuch as the SFN-mediated inhibition of the inflammasomes was independent of caspase-1 activity, ROS modulation, and Nrf2 synthesis [66]

Vitamin D3 is essential, as deficiency is widespread in children with ASD, and supplementation has been linked to improvements in eye contact, communication, and social behaviors

On the other hand, increased oxidative stress can increase DNA methylation (hypermethylation), leading to increased utilization of methyl groups (225, 226)

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