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However, the mechanisms by which tumor cells coordinate TME stimuli and their unique metabolic traits to evade ferroptosis and develop resistance to immunotherapy remain unclear

Cell death serves not only as a physiological mechanism controlling normal development and tissue balance, but also as a pathological process triggering organ dysfunction and causing local or systemic inflammation

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Existing studies have shown that the main features of depression are abnormal neurotransmitter levels in patients, abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis, hormonal imbalance in the organism with inflammation and oxidative stress, neurotrophic factors, tryptophan metabolism, and the occurrence of gut microbiota-related diseases, as shown in Figure 1

Meanwhile, complement activation and antibody-mediated damage add additional layers of destruction