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In conclusion, clinical trials for SCA3 have been sparse and underwhelming in terms of their power to detect change, yet there are several advances and opportunities that should allow for a sorely needed increase in the number of interventional studies that can be performed

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Biomolecules 11 , 589 (2021)

Unfortunately, many species are decreasing in population, and some have become extinct (IUCN, 2022)

However, since many cell lines are strictly dependent on exogenous serine for proliferation, we hypothesized that NKX2-1 overexpression could overcome this limitation