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Cutfield W, S, Lundgren F: Insulin-Like Growth Factor I and Growth Responses during the First Year of Growth Hormone Treatment in KIGS Patients with Idiopathic Growth Hormone Deficiency, Acquired Growth Hormone Deficiency, Turner Syndrome and Born Small for Gestational Age

The core philosophy is to "close the window first," mitigating these primary causes before addressing the subsequent aging markers

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However, its specific mechanisms in DOR remain unclear

Int J Herb Med 4(3):2127 Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription