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Moreover, NRF2 is required for the survival of hematopoietic stem progenitor cells (HSPCs) and the development of myeloid cells in mice, as NRF2 KO bone marrow had defect in stem cell function and showed reduction of chimerism after transplantation [124]

The study is sufficiently powered when the incidence rate of the outcome of interest in the exposed individuals is significantly different from the unexposed group (Kang 2021)

Diarrhea Diarrhea is the second most common gastrointestinal side effect, reported in 10.1% to 29.7% of semaglutide users in clinical trials

Since MK-677 is not authorized for human application, there is a lack of published specific contraindications