Glutathione-mediated biotic stress tolerance in plants, in Glutathione in Plant Growth, Development, and Stress Tolerance , eds HossainM
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Not only is GSH regulated by Nrf2, the thioredoxin-based antioxidant system (TXN1, TXNRD1) is also regulated by Nrf2, indicating that Nrf2 regulates the redox state of proteins (Reisman et al., 2009)
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This creates feedback inhibition on Phase II enzymes and increases the toxic burden on Phase III hepatocyte transporters