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When ERS is severe and persistent, the expression of GADD153/CHOP and caspase-12 can be upregulated, ultimately inducing apoptosis

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Research has studied its roles in ROS scavenging, xenobiotic detoxification via glutathione S-transferases, maintenance of cellular redox state, and immune cell function

doi: 10.3390/ijms22073603 92 Fratta PasiniA