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Metabolites that are significantly higher in suspended culture include putrescine (fold change (FC) biofilm/suspended = 0.04, p = 3.12 10 -6 ), succinate (FC = 0.08, p = 6.25 10 -6 ), glycerophosphocholine (FC = 0.13, p = 2.88 10 -4 ), gamma-aminobutyric acid (FC = 0.31, p = 9.96 10 -5 ), aspartate (FC = 0.31, p = 1.96 10 -3 ), fumarate (FC = 0.32, p = 2.87 10 -2 ), and ethanolamine (FC = 0.39, p = 1.76 10 -4 ) ( Fig 4 , S1 Table )

GSH exerts its biological effects primarily through three pathways: Redox regulation of protein thiols Modulation of the NF-kB signaling pathway, Detoxification reactions catalyzed by glutathione S-transferases (GSTs)

Indeed, the expression of the GSTP1-1 variant Ile105Val is able to increase the effect of lead on the development of ASL 66

Too many exfoliating products can damage the barrier

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