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Analysis of clinical parameters A spectrum of clinical and haematological parameters like CRP, ESR, glucose (random), urea, creatinine, haemoglobin, total lipid profile were analysed from all studied individuals of the SLT-user group (N = 47) and non-user group (N = 44) from their blood using autoanalyzer (Purechem Ltd, Ireland)

Hospital discharge reports from the SDO were anonymized and included relevant information from the patients medical records, including personal data (i.e

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Results Genes enriched by SA-DNAm from blood samples Following the procedure described in Supplementary Figure S1, 28 studies published between 2008 and 2015 were identified, which included 9 candidate GSM studies and 19 EWASs (N = 18,677 subjects