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In CD, infiltrating CD4 + T cells produce a large number of Th1/Th17-associated pro-inflammatory cytokines such as IFN-, IL-17A, and TNF- ( + T cells secrete Th2-associated proinflammatory cytokines, such as IL-4, IL-13, and IL-14 ( NKT cells are also an important part of the immune response in UC pathology: they secrete IL-13, which causes damage in the epithelium, and this consequently generates a positive feedback that increases NKT cell function ( It has been also suggested that humoral immunity has a more relevant etiological role in UC than in CD

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History of National No Smoking Day Ash Wednesday, 1984 marked the beginning of National No Smoking Day in the Republic of Ireland, as the ruling clergy decided that giving up cigarettes for Lent would be a good idea