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Transgenic female mice treated with intranasal GHK-Cu had higher alternation percentages in the Y maze, indicating improved cognitive performance, beginning as early as the second month of treatment (Week 8), and continuing through the third month (Week 12) when the study ended, compared to transgenic mice treated with intranasal saline (Figure 1A)

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For example, piezophiles accumulate low-molecular-weight osmolytes, mainly organic solutes, and increase the proportion of unsaturated fatty acids in the lipid membranes (Casadei et al., 2002