Tanaka et al., in 4,835 Japanese civil servants, reported domain-specific associations between macronutrient energy percentages and insomnia symptoms assessed by three brief items: difficulty initiating sleep (trouble falling asleep), difficulty maintaining sleep (nighttime awakenings), and poor sleep quality
Because it hasn't gone through rigorous clinical trials, we just don't know what a safe dose is, what the short-term side effects are, or what the long-term health consequences could be
Creatines protective activity against radicals also points to its role as an antioxidant [47]
Subbiah V, Hong DS, Amini B, Piha-Paul S, Fernandez JG, Fu S, Tsimberidou AM, Naing A, Janku F, Karp DD, Overman M, Eng C, Kopetz S , Meric-Bernstam F, Falchook GS
Rising hunger, waist growth, weight gain above about 2 lb per month, persistent heart-rate elevation, or declining strength indicate that the lower dose is not maintaining the prior response