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The frailty analysis we performed aimed to test if the results obtained from the MR analysis in this study could be explained by the effects of frailty alone, in which a survival bias due to selective mortality was responsible for the causal estimate between either alcohol consumption or smoking continuation and PD risk

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While pre-specifying the chosen confounders in this analysis strengthens its rigor by minimizing bias, some residual confounders were unmeasured or unaccounted for, influencing the observed relationship that cannot be entirely ruled out

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