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Assay accuracy and precision accuracy were validated on LC-MS/MS by repeated sample quantification by preparing five individual samples of reaction matrix containing 1 ppm cotinine, COX, or 3HC standard, processing them for LC-MS/MS, and immediately measuring cotinine, COX, or 3HC concentrations for each standard sample as compared to individually prepared standard curves all measured by LC-MS/MS as previously described

The bronchial tubes become swollen, produce excess mucus, and create blockages, making airflow restricted

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People didnt smoke significantly more often or more intensely when they switched to the Quest brand, even as their nicotine yield dropped

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