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The STEP 4 trial showed that stopping semaglutide leads to regaining approximately two-thirds of the lost weight within a year

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Moreover, the expression and phosphorylation status of JAKs and STAT3 can be controlled by several microRNAs in a context-dependent manner

While small changes in the scores of these scales might be statistically significant in trials, the impact of such in patients symptoms and quality of life can be meaningless, being important to thoroughly define which score changes are, in fact, impactful [249]

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